In a small saucepan, combine the maple syrup, brown sugar, soy sauce, Dijon mustard, apple cider vinegar, garlic powder, and onion powder. Stir to combine.
Heat the mixture over medium heat, stirring occasionally, until the brown sugar has dissolved and the mixture has thickened slightly, about 5-7 minutes.
Remove the saucepan from the heat and let the glaze cool for a minute or two.
Taste the glaze and adjust the seasoning as needed with salt and pepper.
Brush the glaze onto your cooked meats or vegetables, or drizzle it over your desserts, and serve immediately.